What question did this study set out to answer?

To assess thirst and plasma vasopressin responses to intravenous angiotensin II infusions in healthy humans.

June 1, 1985Clinical Science

Angiotensin II-induced thirst and vasopressin release in man

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Why the study?

Does intravenous angiotensin II infusion stimulate thirst and vasopressin release in healthy young men?

Population

10 healthy young men

Comparison

Intravenous angiotensin II infusions vs Control (single-blind controlled)

Design

Single-blind

Authors

PPPaddy A. PhillipsFlinders University BRBarbara J. RollsPennington Biomedical Research Center JLJ LedinghamAustralian National University

Discussion

Member takes

Implication

Angiotensin II unlikely to mediate thirst or vasopressin at physiological levels in healthy men; leaves open effects in disease states.

Key Points

To assess thirst and plasma vasopressin responses to intravenous angiotensin II infusions in healthy humans.
Administered single-blind controlled intravenous infusions of angiotensin II at doses ranging from 2 to 16 ng·min⁻¹·kg⁻¹ to 10 healthy young men.
Angiotensin II infusions stimulated thirst and vasopressin secretion in 4 out of 10 subjects.
Responses occurred only at plasma angiotensin concentrations substantially exceeding physiological levels observed during water deprivation.

Structured PICO

Does intravenous angiotensin II infusion stimulate thirst and vasopressin release in healthy young men?

Population

10 healthy young men

Intervention

Intravenous angiotensin II infusions (2-16 ng min-1 kg-1)

Comparator

Control (single-blind controlled)

Outcome

Thirst and plasma vasopressin responsessurrogate

Intravenous angiotensin II stimulates thirst and vasopressin release only at supraphysiological concentrations in a subset of healthy men.

Limitations

Small sample size
Unclear why only certain individuals respond

Cite This Study

Phillips et al. (1985) studied this question.

synapsesocial.com/papers/6a726dfcfe4101aa97e0d92a https://doi.org/10.1042/cs0680669

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Bookmark

Angiotensin II-induced thirst and vasopressin release in man

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Angiotensin II-induced thirst and vasopressin release in man

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider