What question did this study set out to answer?

This research aims to examine if angiotensin II directly stimulates arginine-vasopressin release and its role under varying conditions.

August 1, 1977Journal of Endocrinology

Effects of Angiotensin Ii on Arginine-Vasopressin in Physiological and Pathological Situations in Man

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Authors

PPPaul L. PadfieldGeneral / Preventive / Lipids JMJ J MortonWestern Infirmary

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Implication

Randomized trial explores the role of angiotensin II on vasopressin levels in normal and pathological conditions, suggesting minimal direct influence.

Key Points

This research aims to examine if angiotensin II directly stimulates arginine-vasopressin release and its role under varying conditions.
Acute infusion of angiotensin II was administered to normal volunteers.
Plasma levels of arginine-vasopressin were measured during physiological changes and in conditions with high angiotensin II levels.
Comparative assessments were made in clinical scenarios like Addison's disease and Bartter's syndrome.
Angiotensin II infusion led to a small increase in arginine-vasopressin levels from 5.4 to 6.4 pg/ml with supraphysiological angiotensin II levels.
No consistent direct effect of angiotensin II on arginine-vasopressin regulation was observed in normal physiological states.
Findings suggest limited relevance of angiotensin II in the normal control of vasopressin release.

Cite This Study

Padfield et al. (1977) studied this question.

synapsesocial.com/papers/6a66d29edf8ec4ba454b228c https://doi.org/10.1677/joe.0.0740251

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Implication

Randomized trial explores the role of angiotensin II on vasopressin levels in normal and pathological conditions, suggesting minimal direct influence.

Effects of Angiotensin Ii on Arginine-Vasopressin in Physiological and Pathological Situations in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Angiotensin Ii on Arginine-Vasopressin in Physiological and Pathological Situations in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

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