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August 24, 2022Frontiers in PhysiologyOpen Access

Computational models of ventricular mechanics and adaptation in response to right-ventricular pressure overload

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Why the study?

The right ventricle remains understudied compared to the left ventricle, and improving diagnosis and treatment in pulmonary arterial hypertension requires a better understanding of right ventricular growth and remodeling mechanisms.

Design

Review

Authors

OOOscar O. OdeigahDVDaniela Valdez‐JassoSWSamuel Wall

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Overview

RV-focused assessment may improve PAH risk stratification; leaves open whether RV-targeted therapies alter outcomes.

Structured PICO

P
Population
Computational models of right ventricular mechanics and adaptation in response to right-ventricular pressure overload, specifically in the context of pulmonary arterial hypertension (PAH).

Computational models provide a valuable supplement to experimental research for understanding the drivers and mechanisms of right ventricular growth and remodeling in pulmonary arterial hypertension.

Cite This Study

Odeigah et al. (2022) studied this question.

synapsesocial.com/papers/6a726fc0f44fa9f079dfeb84https://doi.org/10.3389/fphys.2022.948936
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Computational modelling of multi-temporal ventricular–vascular interactions during the progression of pulmonary arterial hypertension2022 · 5 citations
  2. 2A computational study of right ventricular mechanics in a rat model of pulmonary arterial hypertension2024 · 7 citations
  3. 3Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited2007 · 27 citations
  4. 4Combining computer modelling and cardiac imaging to understand right ventricular pump function2017 · 20 citations
  5. 5Distinct right ventricle remodeling in response to pressure overload in the rat2016 · 41 citations