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January 30, 1981Science

Myosin Phosphorylation and the Cross-Bridge Cycle in Arterial Smooth Muscle

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Population

Arterial smooth muscle

Design

Preclinical

Authors

PDPatrick F. DillonUniversity of VirginiaMAMark O. AksoyTemple University HospitalSDSteven P. DriskaTemple University

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Overview

Offers mechanistic basis for sustained arterial tone in animals; leaves open human relevance and clinical translation.

Structured PICO

P
Population
Arterial smooth muscle
I
Intervention
Dephosphorylation of the 20,000-dalton light chain of myosin
O
Outcome
Cross-bridge cycling and force maintenancesurrogate

Demonstrates the mechanistic role of myosin light chain dephosphorylation in creating latch-bridges for efficient force maintenance in arterial smooth muscle.

Cite This Study

Dillon et al. (1981) studied this question.

synapsesocial.com/papers/6a7270543ce530166bc352cehttps://doi.org/10.1126/science.6893872
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ca‐Linked Phosphorylation of a Light Chain of Vertebrate Smooth‐Muscle Myosin1977 · 196 citations
  2. 2Variation of muscle stiffness with force at increasing speeds of shortening.1975 · 158 citations
  3. 3Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation.1977 · 305 citations
  4. 4Length-Tension Relationship of Smooth Muscle of the Hog Carotid Artery1973 · 311 citations
  5. 5Cross‐bridge detachment and sarcomere 'give' during stretch of active frog's muscle.1978 · 282 citations