March 1, 1983AJP Cell Physiology

Myosin phosphorylation and regulation of cross-bridge cycle in tracheal smooth muscle

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Population

Rabbit tracheal smooth muscle

Comparison

Carbachol (10(-5) M) vs Resting muscle

Design

Preclinical

Authors

WGWilliam T. GerthofferUniversity of Nevada, Reno RMRichard A. MurphyUniversity of Southern California

Discussion

Member takes

Implication

Supports LC20 phosphorylation regulating smooth muscle velocity in rabbits; leaves open translation to human airway disease.

Structured PICO

Population

Rabbit tracheal smooth muscle

Intervention

Carbachol (10(-5) M)

Comparator

Resting muscle

Outcome

LC 20 phosphorylation and isotonic shortening velocitysurrogate

In rabbit tracheal smooth muscle, myosin light chain phosphorylation correlates with shortening velocity, suggesting it regulates the mean cross-bridge cycling rate.

Cite This Study

Gerthoffer et al. (1983) studied this question.

synapsesocial.com/papers/6a81e6cf2ac899ae0206e55f https://doi.org/10.1152/ajpcell.1983.244.3.c182

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