What question did this study set out to answer?

To determine the dose-peak effect relationship and 24-hour blood pressure response of lisinopril across multiple dosage levels in patients with mild to moderate essential hypertension.

May 1, 1988British Journal of Clinical PharmacologyOpen Access

Lisinopril: dose‐peak effect relationship in essential hypertension.

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Authors

VCVJ CirilloMerck & Co., Inc., Rahway, NJ, USA (United States)HGHJ GomezMerck & Co., Inc., Rahway, NJ, USA (United States)JSJuha SalonenMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

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Implication

Randomized double-blind trial shows similar peak effects for 10 mg and 20 mg lisinopril in essential hypertension, suggesting initial 20 mg dosing carries no greater hypotension risk than 10 mg.

Key Points

To determine the dose-peak effect relationship and 24-hour blood pressure response of lisinopril across multiple dosage levels in patients with mild to moderate essential hypertension.
Double-blind, parallel-group randomized trial in 83 patients with mild to moderate essential hypertension (supine diastolic blood pressure 95–115 mm Hg).
Following a 4-week placebo washout period, participants were randomized to receive 2.5, 10, 20, or 80 mg day⁻¹ of lisinopril for 1 week.
Lisinopril 10 mg and 20 mg daily produced peak blood pressure reductions greater than the 2.5 mg dose, but less than the 80 mg dose, with no apparent difference in peak magnitude between 10 mg and 20 mg.
The antihypertensive effect at 24 hours post-administration displayed a consistent dose-dependent increase across the 2.5 to 80 mg day⁻¹ range.

Cite This Study

Cirillo et al. (1988) studied this question.

synapsesocial.com/papers/6a72724cfe4101aa97e0da53 https://doi.org/10.1111/j.1365-2125.1988.tb03342.x

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Implication

Randomized double-blind trial shows similar peak effects for 10 mg and 20 mg lisinopril in essential hypertension, suggesting initial 20 mg dosing carries no greater hypotension risk than 10 mg.

Lisinopril: dose‐peak effect relationship in essential hypertension.

Discussion

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Implication

Key Points

Cite This Study

Lisinopril: dose‐peak effect relationship in essential hypertension.

Discussion

Member takes

Implication

Key Points

Cite This Study

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