Key result
Lisinopril (initial dose 0.07 mg/kg once daily) effectively lowered blood pressure in a dose-dependent fashion within 2 weeks in hypertensive children.
Why the study?
Does lisinopril reduce blood pressure in hypertensive children aged 6 to 16 years?
Population
115 hypertensive children, aged 6 to 16 years.
Comparison
Lisinopril once daily at three doses by body… vs Placebo and lower doses of lisinopril.
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
up to 4 weeks (2 weeks initial + up to 2 weeks withdrawal)
Authors
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Focus on clinical utility and research extension):**.
RCT (n=115)
Double-blind
randomized
Does lisinopril reduce blood pressure in hypertensive children aged 6 to 16 years?
Lisinopril is an effective and well-tolerated once-daily antihypertensive for children aged 6 to 16 years, demonstrating a dose-dependent reduction in blood pressure.
Beth A. Soffer (2003) conducted an RCT in hypertension (n=115). Lisinopril vs. Placebo was evaluated on Change in slope in sitting diastolic and systolic blood pressure by dose after 2 weeks of therapy compared to baseline. Lisinopril (initial dose 0.07 mg/kg once daily) effectively lowered blood pressure in a dose-dependent fashion within 2 weeks in hypertensive children.
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