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August 1, 2002The Journal of Clinical Pharmacology

A Double‐Blind, Placebo‐Controlled, Dose‐Response Study of the Effectiveness and Safety of Enalapril for Children with Hypertension

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Why the study?

Does enalapril reduce trough sitting diastolic blood pressure in hypertensive children ages 6 to 16 years?

Population

110 hypertensive children ages 6 to 16 years

Comparison

Enalapril once daily for 2 weeks vs Placebo

Design

RCT, Stratified by weight, then assigned to one of three dosing groups…

Follow-up

4 weeks

Authors

TWThomas G. WellsLeiden UniversityVFVirginia FrameCSL (United States)BSBeth A. SofferMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

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Implication

Supports enalapril dosing in hypertensive children 6-16 years; extends adult RCT evidence with pediatric dose-response confirmation.

Structured PICO

Does enalapril reduce trough sitting diastolic blood pressure in hypertensive children ages 6 to 16 years?

P
Population
110 hypertensive children ages 6 to 16 years
I
Intervention
Enalapril once daily (low: 0.625 or 1.25 mg, middle: 2.5 or 5 mg, or high dose: 20 or 40 mg based on weight) for 2 weeks
C
Comparator
Placebo (during the 2-week randomized withdrawal phase)
O
Outcome
Trough (24-h postdose) sitting diastolic blood pressuresurrogate

Enalapril effectively and safely lowers blood pressure in a dose-dependent manner in hypertensive children.

Cite This Study

Wells et al. (2002) studied this question.

synapsesocial.com/papers/6a898332ab4588dbccfb93cdhttps://doi.org/10.1177/009127002401102786

Topics

Hypertension management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Report of the Second Task Force on Blood Pressure Control in Children—19871987 · 1,149 citations
  2. 2Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: A Working Group Report from the National High Blood Pressure Education Program1996 · 999 citations
  3. 3Hypertension-induced cardiac damage in children and adolescents1999 · 16 citations
  4. 4Adolescent Hypertension1974 · 124 citations