Why the study?
Do halothane and enflurane affect conduction velocity and Vmax differently than fast sodium channel blockers in isolated guinea pig papillary muscles?
Population
isolated guinea pig papillary muscles
Comparison
halothane and enflurane vs fast sodium channel blockers
Design
Preclinical
Authors
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Distinguishes volatile anesthetic conduction effects from sodium channel blockade in vitro; leaves open clinical relevance for arrhythmia risk in patients.
Do halothane and enflurane affect conduction velocity and Vmax differently than fast sodium channel blockers in isolated guinea pig papillary muscles?
Volatile anesthetics halothane and enflurane decrease conduction velocity via a mechanism distinct from fast sodium channel blockers, warranting caution in patients with conduction disease or on class 1 antiarrhythmics.
Ozaki et al. (1989) studied this question.
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