October 1, 1992British Journal of PharmacologyOpen Access

Effects of propofol and enflurane on action potentials, membrane currents and contraction of guinea‐pig isolated ventricular myocytes

View Full Paper

Ask AI

Bookmark

Population

Single myocytes isolated from guinea-pig ventricles

Design

Preclinical

Authors

RPRosalind M. PuttickUniversity of Oxford DTDerek A. TerrarUniversity of Oxford

Discussion

Member takes

Implication

These guinea-pig myocyte effects leave open clinical relevance during anesthesia; hypothesis-generating for human calcium handling studies.

Structured PICO

Population

Single myocytes isolated from guinea-pig ventricles

Intervention

Propofol and enflurane

Outcome

Action potentials, membrane currents, and contractionsurrogate

Propofol and enflurane exert negative inotropic effects in guinea-pig ventricular myocytes partly by reducing calcium influx, with enflurane additionally impairing sarcoplasmic reticulum calcium handling.

Cite This Study

Puttick et al. (1992) studied this question.

synapsesocial.com/papers/6a76fa7e2e130d02afec4ceb https://doi.org/10.1111/j.1476-5381.1992.tb12783.x

View Full Paper

Ask AI

Bookmark

Implication

These guinea-pig myocyte effects leave open clinical relevance during anesthesia; hypothesis-generating for human calcium handling studies.

Effects of propofol and enflurane on action potentials, membrane currents and contraction of guinea‐pig isolated ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of propofol and enflurane on action potentials, membrane currents and contraction of guinea‐pig isolated ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider