Population
Single myocytes isolated from guinea-pig ventricles
Design
Preclinical
Authors
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May contribute to anesthetic negative inotropy; hypothesis-generating in animal models and leaves open human relevance.
Propofol and enflurane alter the kinetics of L-type calcium channels to favor the closed state, which may contribute to the negative inotropic action of these anesthetics.
Takahashi et al. (1994) studied this question.
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