In porcine aortic valves, regions with dilute collagen fiber networks are subjected to higher stress magnitudes and are more prone to damage, highlighting the importance of local collagen distribution on valve mechanics.
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CFN variations may refine local stress predictions in AV models; leaves open clinical translation to valve design.
The cusps of native aortic valve (AV) are composed of collagen bundles embedded in soft tissue, creating a heterogenic tissue with asymmetric alignment in each cusp. This study compares native collagen fiber networks (CFNs) with a goal to better understand their influence on stress distribution and valve kinematics. Images of CFNs from five porcine tricuspid AVs are analyzed and fluid-structure interaction models are generated based on them. Although the valves had similar overall kinematics, the CFNs had distinctive influence on local mechanics. The regions with dilute CFN are more prone to damage since they are subjected to higher stress magnitudes.
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Mega et al. (2015) studied this question.
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