April 19, 2007Journal of Biomechanical Engineering

In-Situ Deformation of the Aortic Valve Interstitial Cell Nucleus Under Diastolic Loading

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Population

Porcine aortic valves

Design

Preclinical

Authors

HHHsiao‐Ying Shadow HuangNorth Carolina State University JLJun LiaoChina Pharmaceutical University MSMichael S. SacksStructural Heart Disease

Discussion

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Implication

Pressure-induced AVIC nuclear deformation in animals may influence valve remodeling; extends mechanobiology data but leaves open human relevance.

Structured PICO

Population

Porcine aortic valves

Intervention

Transvalvular pressure loading (0-90 mm Hg)

Outcome

Change in nuclear aspect ratio (NAR) and local collagen fiber alignmentsurrogate

Transvalvular pressure induces significant deformation of aortic valve interstitial cell nuclei, which correlates with tissue microstructure and collagen fiber alignment.

Cite This Study

Huang et al. (2007) studied this question.

synapsesocial.com/papers/6a8a5ff1f8670bac6e3372ca https://doi.org/10.1115/1.2801670

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Implication

Pressure-induced AVIC nuclear deformation in animals may influence valve remodeling; extends mechanobiology data but leaves open human relevance.

In-Situ Deformation of the Aortic Valve Interstitial Cell Nucleus Under Diastolic Loading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In-Situ Deformation of the Aortic Valve Interstitial Cell Nucleus Under Diastolic Loading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider