Key result
Applied tissue strains fail to directly transfer to the aortic valve fibrous network, causing nonuniform strain.
Why the study?
There is little data on the correlation between tissue level and fibrous network-level strains in the aortic valve, which is important for understanding strain transfer and microstructural modeling.
Population
Aortic valve samples
Comparison
Applied tissue level strains vs local fibrous network strains
Design
Preclinical experimental study
Authors
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Challenges affine strain assumptions in valve models; leaves open effects on human interstitial cell mechanobiology.
Strain transfer through the aortic valve tissue to its fibrous network is nonaffine, inhomogeneous, and anisotropic, which may expose interstitial cells to shear strains and stresses.
Anssari-Benam et al. (2012) studied Aortic valve biomechanics. Applied tissue level strains was evaluated on Correlation between applied strains at tissue level, macrostrains across the tissue surface, and local fibrous network strains. Applied tissue level strains did not directly transfer to the fibrous network of the aortic valve, resulting in inhomogeneous, nonuniform, and anisotropic strain distributions.
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