Why the study?
Do polymorphisms in the tissue factor pathway inhibitor (TFPI) gene increase the risk of acute coronary syndromes?
Population
130 patients with acute coronary syndromes and 142 healthy controls
Comparison
Presence of tissue factor pathway inhibitor gene… vs Absence of the polymorphisms (common genotypes)
Design
Case-control
Authors
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No support for TFPI V264M in ACS risk assessment; confirms null association in larger cohorts while leaving other variants untested.
Do polymorphisms in the tissue factor pathway inhibitor (TFPI) gene increase the risk of acute coronary syndromes?
Polymorphisms in the tissue factor pathway inhibitor (TFPI) gene, including the V264M variant, do not appear to be significantly associated with the overall risk of acute coronary syndromes.
Moatti et al. (1999) studied this question.
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