Why the study?
Are the T-287C and C-399T polymorphisms in the TFPI gene associated with an increased risk of coronary heart disease or altered TFPI levels?
Population
Cases with coronary heart disease and controls
Comparison
Presence of T-287C and C-399T polymorphisms in… vs Absence of these polymorphisms
Design
Case-control
Authors
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No change to CHD risk stratification warranted; leaves open mechanistic effects on TFPI and F1+2 for further study.
Are the T-287C and C-399T polymorphisms in the TFPI gene associated with an increased risk of coronary heart disease or altered TFPI levels?
The T-287C and C-399T polymorphisms in the TFPI gene influence TFPI expression and coagulation markers but do not appear to increase the overall risk of coronary heart disease.
Moatti et al. (2000) studied this question.
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