April 1, 2001Blood
Identification of polymorphisms in the promoter and the 3′ region of the TAFI gene: evidence that plasma TAFI antigen levels are strongly genetically controlled
Key result
Polymorphic variations in the promoter and 3'UTR of the TAFI gene strongly determine circulating TAFI antigen levels, with specific combinations explaining up to 61.6% of the variance.
Why the study?
Do polymorphisms in the promoter and 3'UTR of the TAFI gene determine plasma TAFI antigen levels?
Population
Individuals assessed for plasma TAFI antigen levels
Design
Other
Authors
Discussion
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Member takes
Implication
Future TAFI studies must adjust for these variants; leaves open their impact on atherothrombotic outcomes.
Study Design
Type
Observational
Structured PICO
Do polymorphisms in the promoter and 3'UTR of the TAFI gene determine plasma TAFI antigen levels?
P
Population
Individuals assessed for plasma TAFI antigen levels (specific demographics and sample size not stated in abstract)
E
Exposure
Genotyping for polymorphisms in the promoter and 3'-untranslated region of the TAFI gene
O
Outcome
Variance in plasma TAFI antigen levels explained by genetic polymorphismssurrogate
Circulating levels of TAFI, a potential factor in atherothrombotic diseases, are strongly genetically determined by polymorphic variations in the TAFI gene.
Cite This Study
Henry et al. (2001) reported an observational. Polymorphisms in the promoter and 3'UTR of the TAFI gene was evaluated on Plasma TAFI antigen levels. Polymorphic variations in the promoter and 3'UTR of the TAFI gene strongly determine circulating TAFI antigen levels, with specific combinations explaining up to 61.6% of the variance.