Plasma Thrombin-Activatable Fibrinolysis Inhibitor Antigen Concentration and Genotype in Relation to Myocardial Infarction in the North and South of Europe
Why the study?
Are plasma TAFI levels and TAFI gene polymorphisms associated with the risk of myocardial infarction in European men?
Population
1,251 men, comprising 598 cases recruited 3 to 6 months after myocardial infarction and 653 age-matched…
Comparison
Plasma TAFI antigen levels and TAFI gene… vs Age-matched controls without recent MI
Design
Case-control
Authors
Discussion
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Member takes
Implication
High TAFI Ag levels should not guide MI risk assessment; leaves open protective causality pending prospective validation.
Structured PICO
Are plasma TAFI levels and TAFI gene polymorphisms associated with the risk of myocardial infarction in European men?
P
Population
1,251 men, comprising 598 cases recruited 3 to 6 months after myocardial infarction and 653 age-matched controls, from North Europe (Sweden, England) and South Europe (France, Italy).
I
Intervention
Plasma TAFI antigen levels and TAFI gene polymorphisms (Ala147Thr and C+1542G)
C
Comparator
Age-matched controls without recent MI
O
Outcome
Risk of myocardial infarctionhard clinical
Elevated plasma TAFI antigen levels and specific TAFI gene polymorphisms are associated with a lower risk of myocardial infarction, suggesting a potential protective effect.
Cite This Study
Juhan‐Vague et al. (2002) studied this question.