Why the study?
Does inhibition of BKCa channels improve vascular membrane potential and vasoreactivity in animal models of hemorrhagic shock?
Does inhibition of BKCa channels improve vascular membrane potential and vasoreactivity in animal models of hemorrhagic shock?
Hypersensitivity of BKCa channels to Ca2+ sparks underlies vascular hyporeactivity in hemorrhagic shock, suggesting BKCa inhibition as a potential therapeutic target.
No takes yet. Share an insight, caveat, or question.
BK(Ca) hypersensitivity may underlie hypotension in hemorrhagic shock; leaves open therapeutic targeting pending clinical studies.
Zhao et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: