Why the study?
Does membrane potential depolarization alter the coupling of Ca2+ sparks to BKCa channels in urinary bladder smooth muscle?
Population
Urinary bladder smooth muscle (UBSM)
Comparison
Membrane potential depolarization vs Baseline membrane potential (-50 mV)
Design
Preclinical
Authors
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Depolarization strengthens Ca2+ spark-BKCa coupling in bladder myocytes; leaves open relevance to human detrusor function or disease.
Does membrane potential depolarization alter the coupling of Ca2+ sparks to BKCa channels in urinary bladder smooth muscle?
Membrane potential profoundly alters the coupling strength of Ca2+ sparks to BKCa channels in urinary bladder smooth muscle, primarily due to the voltage dependence of the Ca2+ sensitivity of BKCa channels.
Herrera et al. (2001) studied this question.
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