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January 23, 1998Circulation ResearchOpen Access

Cardiac Myosin Binding Protein C Gene Is Specifically Expressed in Heart During Murine and Human Development

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Population

Human embryos (from 4 weeks of development) and murine embryos (from embryonic day 9.5 until birth)

Design

Preclinical

Authors

FFFrançoise FougerousseADAnne‐Lise DelezoideMFMarc Fiszman

Discussion

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Overview

Early cardiac MyBP-C expression is heart-restricted; leaves open mechanistic roles in hypertrophic cardiomyopathy and model utility.

Key Points

  • To determine the spatiotemporal expression pattern of the cardiac MyBP-C gene during human and murine embryonic development to better understand familial hypertrophic cardiomyopathy.
  • Performed in situ hybridization using species-specific oligonucleotide probes on human embryos starting from 4 weeks of development.
  • Tracked cardiac MyBP-C mRNA distribution in murine embryos from embryonic day 9.5 through birth.
  • Detected strong cardiac MyBP-C mRNA expression throughout all heart compartments in human embryos from 4 weeks of development, with no signal in somites.
  • Observed strong, exclusive cardiac MyBP-C expression in the embryonic mouse heart from day 9.5 until birth, demonstrating mammalian-specific cardiac restriction.

Structured PICO

P
Population
Human embryos (from 4 weeks of development) and murine embryos (from embryonic day 9.5 until birth)
I
Intervention
In situ hybridization using species-specific oligonucleotide probes
O
Outcome
Expression pattern of the cardiac MyBP-C gene

The cardiac MyBP-C gene is specifically expressed in the developing human and murine heart, providing a basis for understanding familial hypertrophic cardiomyopathy pathophysiology and developing animal models.

Cite This Study

Fougerousse et al. (1998) studied this question.

synapsesocial.com/papers/6a727e03febe604dd70aa23dhttps://doi.org/10.1161/01.res.82.1.130
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of myosin heavy chain in neonatal human hearts1992 · 11 citations
  2. 2Familial hypertrophic cardiomyopathy: a genetic model of cardiac hypertrophy1995 · 104 citations
  3. 3Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides.1994 · 52 citations
  4. 4The interaction of C-protein with heavy meromyosin and subfragment-21978 · 179 citations
  5. 5The C-proteins of rabbit red, white, and cardiac muscles.1983 · 130 citations