Population
SV40-transformed REF52 cell line (WT1A cells) in serum-free medium
Comparison
Purified lipid-free human HDL-apolipoproteins vs Native whole HDL
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of apolipoprotein effects to human cardiovascular models.
The growth-promoting effect of HDL on WT1A cells is mediated by apolipoproteins A-I and C-III, independent of HDL-associated lipid uptake.
Chen et al. (1986) studied this question.
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