Population
Human peripheral blood lymphocytes from healthy donors and low density lipoprotein receptor-defective patients
Design
Preclinical
Authors
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HDL lipid exchange mechanisms warrant no clinical extrapolation from animal data; hypothesis-generating for apoAI roles in human immunity and atherosclerosis.
HDL promotes lymphocyte growth via both binding-dependent and binding-independent mechanisms of lipid exchange, mediated primarily by apoAI.
Jürgens et al. (1989) studied this question.
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