December 4, 1978Proceedings of the Royal Society B Biological Sciences

A re-examination of curare action at the motor endplate

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Population

Motor endplate

Comparison

Curare, gallamine, and pancuronium vs Alpha-bungarotoxin

Design

Preclinical

Authors

BKBernard KatzTotal (France)RMRicardo MilediAustralian National University

Discussion

Member takes

Implication

Curare may induce voltage-dependent open-channel block at the motor endplate; leaves open relevance to human neuromuscular transmission.

Structured PICO

Population

Motor endplate

Intervention

Curare (greater than 5 micrometer), gallamine, and pancuronium

Comparator

Alpha-bungarotoxin

Outcome

Lifetime of the open channel and kinetic behaviour of endplate channelssurrogate

Curare, gallamine, and pancuronium exhibit non-competitive blocking of open ionic channels at the motor endplate, altering channel kinetics through rapidly repeated blocking and unblocking.

Cite This Study

Katz et al. (1978) studied this question.

synapsesocial.com/papers/6a7285b4a7fbea1e4408afdb https://doi.org/10.1098/rspb.1978.0096

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Bookmark

A re-examination of curare action at the motor endplate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A re-examination of curare action at the motor endplate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider