Why the study?
Do demographic factors (age, sex, smoking, oral contraceptives) influence protein C activity in healthy volunteers?
Population
9,648 healthy blood donors
Design
Cross-sectional
Authors
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May support age- and sex-specific protein C reference ranges; hypothesis-generating and requires prospective validation.
Do demographic factors (age, sex, smoking, oral contraceptives) influence protein C activity in healthy volunteers?
Protein C activity varies significantly by age, sex, and oral contraceptive use, necessitating age- and sex-restricted reference ranges for accurate clinical interpretation.
Tait et al. (1993) studied this question.
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