Key Points
- This research aims to determine the presence of T-type Ca2+ currents in hypertrophied adult feline left ventricular myocytes.
- Included 21 hypertrophied adult feline left ventricular myocytes
- Used voltage clamp techniques for current isolation
- Analyzed macroscopic T-type and L-type Ca2+ currents
- T-type Ca2+ currents were found in 15 of 21 hypertrophied myocytes with a peak of -1.8 +/- 0.9 pA/pF
- No T-type currents were observed in 17 normal adult myocytes
- Indicates potential risk for arrhythmias in hypertrophied myocardium due to spontaneous action potentials.
Structured PICO
PPopulationAdult feline left ventricular myocytes (n=21 with long-standing pressure-overload-induced hypertrophy, n=17 normal)
IInterventionLong-standing pressure-overload-induced hypertrophy
CComparatorNormal adult feline ventricular myocytes
OOutcomePresence of macroscopic T-type Ca2+ currentssurrogate
T-type Ca2+ channels are reexpressed in adult feline ventricular myocytes following long-standing pressure-overload-induced hypertrophy, which may increase the likelihood of arrhythmias.