July 1, 1988Diabetes

Beneficial Effects of Verapamil in Diabetic Cardiomyopathy

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Why the study?

Does verapamil improve cardiac function and ultrastructure in a rat model of diabetic cardiomyopathy?

Structured PICO

Does verapamil improve cardiac function and ultrastructure in a rat model of diabetic cardiomyopathy?

Population

Rats made diabetic by an intravenous injection of streptozocin (65 mg/kg)

Intervention

Verapamil (2, 4, or 8 mg/kg/day) for 4 weeks, starting 4 weeks after the induction of diabetes

Comparator

Untreated diabetic rats

Outcome

Cardiac function (heart rate, rate of contraction, rate of relaxation, peak left ventricular systolic pressure, left ventricular diastolic pressure), ultrastructure, and high-energy phosphate storessurrogate

Verapamil prevents diabetes-induced myocardial changes in a rat model, supporting the role of calcium overload in the pathogenesis of diabetic cardiomyopathy.

Discussion

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Implication

Verapamil may attenuate diabetic cardiomyopathy features in rats; leaves open calcium channel blockade as a human therapeutic target.

Cite This Study

Afzal et al. (1988) studied this question.

synapsesocial.com/papers/6a728aeae5469ee92be2744e https://doi.org/10.2337/diab.37.7.936

Topics

Cardiomyopathy

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Beneficial Effects of Verapamil in Diabetic Cardiomyopathy

Structured PICO

Discussion

Implication

Cite This Study

Topics

Beneficial Effects of Verapamil in Diabetic Cardiomyopathy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider