Influence of verapamil on some subcellular defects in diabetic cardiomyopathy

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Why the study?

Does verapamil improve subcellular defects in diabetic cardiomyopathy in a rat model?

Structured PICO

Does verapamil improve subcellular defects in diabetic cardiomyopathy in a rat model?

Population

Sprague-Dawley rats made diabetic with a single injection of streptozotocin (65 mg/kg)

Intervention

Verapamil (8 mg/kg daily for 4-8 wk)

Comparator

Control rats (untreated diabetic and non-diabetic controls)

Outcome

Cardiac myofibrillar ATPase activity, myosin ATPase, myosin isoenzyme profile, sarcoplasmic reticular Ca2+ uptake, and ATPase activitiessurrogate

Verapamil normalizes subcellular organelle defects in a rat model of diabetic cardiomyopathy, likely by modulating calcium entry.

No takes yet. Share an insight, caveat, or question.

Hypothesis-generating for calcium modulation in diabetic cardiomyopathy; should not change practice pending human data.

Afzal et al. (1989) studied this question.

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