Why the study?
What are the comparative anti-clotting effects and pharmacokinetics of intravenous Fragmin, Fraxiparine, Clexane, and Orgaran in healthy male volunteers?
Population
12 healthy male volunteers
Comparison
Intravenous administration of three low… vs Cross-over comparison among the four agents
Design
RCT, randomized cross-over
Authors
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Orgaran may allow extended dosing intervals; extends direct PK comparisons of anti-Xa clearance among these agents.
What are the comparative anti-clotting effects and pharmacokinetics of intravenous Fragmin, Fraxiparine, Clexane, and Orgaran in healthy male volunteers?
Orgaran exhibits a longer half-life and lower clearance of anti-Xa activity compared to the low molecular weight heparins Fragmin, Fraxiparine, and Clexane.
Stiekema et al. (1993) studied this question.
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