January 1, 1996Thrombosis and Haemostasis

Low Molecular Weight Heparin and Compression Stockings in the Prevention of Venous Thromboembolism in Neurosurgery

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Why the study?

Does postoperative nadroparin added to graduated compression stockings reduce venous thromboembolism in neurosurgical patients?

Population

485 neurosurgical patients

Comparison

Nadroparin initiated postoperatively, added to… vs Graduated compression stockings (control group)

Design

RCT, randomized, double-blind

Follow-up

56 days

Authors

MNMichael T. NurmohamedReade ARAndry Mampionona RielUniversity of Antananarivo CHC M A HenkensUniversity Medical Center Groningen

Discussion

Member takes

Implication

Supports adding postoperative nadroparin to graduated compression stockings in neurosurgical patients; extends VTE prophylaxis evidence to this high-risk group.

Structured PICO

Does postoperative nadroparin added to graduated compression stockings reduce venous thromboembolism in neurosurgical patients?

Population

485 neurosurgical patients

Intervention

Nadroparin (low molecular weight heparin) initiated postoperatively, added to graduated compression stockings

Comparator

Graduated compression stockings (control group)

Outcome

Venous thromboembolism (VTE) up to Day 10 postoperatively, detected by mandatory venographycomposite

Adding postoperative nadroparin to graduated compression stockings significantly reduces venous thromboembolism in neurosurgical patients without a significant increase in major bleeding.

Cite This Study

Nurmohamed et al. (1996) studied this question.

synapsesocial.com/papers/6a728f59a528af2d65c475a6 https://doi.org/10.1055/s-0038-1650250

Topics

Pulmonary embolism Anticoagulation in AF

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Implication

Supports adding postoperative nadroparin to graduated compression stockings in neurosurgical patients; extends VTE prophylaxis evidence to this high-risk group.