Why the study?
Do large and repeated doses of heparin increase vascular permeability to red blood cells in normal rats?
Do large and repeated doses of heparin increase vascular permeability to red blood cells in normal rats?
In a rat model, large and repeated doses of heparin increase vascular permeability to red blood cells, an effect that is delayed and persists even after blood clotting returns to normal.
Answers are grounded in this paper and cite their sources.
Should not alter heparin dosing in practice; leaves open permeability effects in humans.
The administration of large and repeated doses of heparin to normal rats resulted in increased output of red blood cells into the lymph, comparable to that associated with x-ray induced thrombocytopenia. A considerable lapse of time was observed between the inhibition of blood coagulation and the increase of vascular permeability to red blood cells. The latter was not decreased by return of the blood clotting to normal.
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Yoshimura et al. (1962) studied this question.
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