Why the study?
Does maternal hyperthyroidism alter the expression of cardiac renin-angiotensin system components in rat offspring?
Population
Pregnant Wistar rats and their pups (evaluated on gestational days 18 and 20)
Comparison
Thyroxine administered to pregnant rats from… vs Vehicle (control group)
Design
Preclinical
Follow-up
Until gestational day 18 and 20
Authors
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May inform fetal cardiac programming mechanisms; leaves open translation to human offspring cardiovascular risk.
Does maternal hyperthyroidism alter the expression of cardiac renin-angiotensin system components in rat offspring?
Maternal hyperthyroidism alters fetal cardiac RAS component expression and induces cardiac hypertrophy, potentially predisposing offspring to adult cardiovascular disease.
Lino et al. (2012) studied this question.
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