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DL-Ornithine is readily prepared in a 68% yield by condensing 3-bromopropylphthalimide with ethyl acetamidocyanoacetate and by hydrolyzing the resulting 2-acetamido-2-carbethoxy-5-phthalimidovaleronitrile into DL-ornithine, isolated as the monohydrochloride. 3-Bromopropylphthalimide is obtained in a 57% yield from 3-aminopropanol by reaction with phthalic anhydride, followed by phosphorus tribromide.
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Roger Gaudry (1953) studied this question.
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