March 10, 2018International Journal of Molecular SciencesOpen Access

Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress

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Population

Patients receiving chemotherapy (specifically anthracyclines) at risk for cardiovascular dysfunction

Design

Review

Authors

NQNabeel Quryshi LTLaura ToroMedical College of Wisconsin KAKarima Ait‐AissaUniversity of Iowa

Discussion

Member takes

Implication

Anthracycline cardiotoxicity via oxidative stress warrants monitoring in cancer patients; leaves open mtDNA-targeted cardioprotection strategies.

Structured PICO

Population

Patients receiving chemotherapy (specifically anthracyclines) at risk for cardiovascular dysfunction

Intervention

Telomerase and novel biomarkers (circulating mtDNA, telomere length)

Telomerase activity and novel biomarkers offer promising avenues for the early detection and mitigation of chemotherapy-induced cardiovascular damage.

Cite This Study

Quryshi et al. (2018) studied this question.

synapsesocial.com/papers/6a729a18660549caf2c6b71a https://doi.org/10.3390/ijms19030797

Topics

Cardio-oncology Cardiovascular prevention

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Implication

Anthracycline cardiotoxicity via oxidative stress warrants monitoring in cancer patients; leaves open mtDNA-targeted cardioprotection strategies.

Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider