A Genetic Risk Variant for Myocardial Infarction on Chromosome 6p24 Is Associated With Impaired Central Hemodynamic Indexes
Why the study?
Is the myocardial infarction genetic risk variant at 6p24 associated with impaired central hemodynamic indexes in Caucasian populations?
Population
403 Caucasian individuals, comprising a group free of measured cardiovascular risk factors and a…
Comparison
Single-nucleotide polymorphisms at eight… vs Individuals without the genetic risk variants.
Design
Cross-sectional
Authors
Discussion
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Implication
Association with higher AIx suggests hemodynamic contribution to 6p24 MI risk; hypothesis-generating and requires prospective validation before clinical consideration.
Structured PICO
Is the myocardial infarction genetic risk variant at 6p24 associated with impaired central hemodynamic indexes in Caucasian populations?
P
Population
403 Caucasian individuals, comprising a group free of measured cardiovascular risk factors (n=133) and a community-based replication population (n=270).
I
Intervention
Single-nucleotide polymorphisms (SNPs) at eight myocardial infarction risk loci, specifically the 6p24 variant in the PHACTR1 gene.
C
Comparator
Individuals without the genetic risk variants.
O
Outcome
Noninvasively determined pulse wave analysis (PWA)-derived central hemodynamic indexes (augmentation index [AIx], augmented pressure [AP], time to reflected wave [TrW], central systolic blood pressure [SBP], and diastolic BP [DBP]).surrogate
The myocardial infarction risk variant at 6p24 in the PHACTR1 gene is associated with adverse arterial wave reflection indexes, suggesting a potential hemodynamic mechanism for its cardiovascular risk.
Cite This Study
Patel et al. (2012) studied this question.