What question did this study set out to answer?

The study aims to understand the effects of omapatrilat on blood pressure and resistance artery function in stroke-prone hypertensive rats.

June 1, 2000HypertensionOpen Access

Vasopeptidase Inhibition Has Potent Effects on Blood Pressure and Resistance Arteries in Stroke-Prone Spontaneously Hypertensive Rats

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Why the study?

Does omapatrilat reduce blood pressure and improve resistance artery structure and function in stroke-prone spontaneously hypertensive rats?

Population

10-week-old stroke-prone spontaneously hypertensive rats (SHRSP)

Comparison

Omapatrilat administered orally for 10 weeks vs Untreated stroke-prone spontaneously…

Design

Preclinical

Follow-up

10 weeks

Authors

HIHope D. IntenganMedical Council of Canada ESErnesto L. SchiffrinMedical Council of Canada

Discussion

Member takes

Implication

Omapatrilat improves resistance artery structure in hypertensive rats; leaves open translation to human microvascular remodeling.

Key Points

The study aims to understand the effects of omapatrilat on blood pressure and resistance artery function in stroke-prone hypertensive rats.
Ten-week-old stroke-prone spontaneously hypertensive rats were treated orally with omapatrilat (40 mg/kg per day) for 10 weeks.
Mesenteric arteries were studied using a pressurized myograph to assess functional changes after treatment.
Systolic blood pressure and vascular metrics were measured pre- and post-treatment.
Omapatrilat significantly reduced systolic blood pressure from 230 mm Hg to 145 mm Hg (P<0.05).
Endothelium-dependent relaxation improved with acetylcholine (10(-5) mol/L) after treatment.
Media width and media/lumen ratio significantly decreased (P<0.05), with a trend towards increased lumen diameter (P=0.07).

Structured PICO

Does omapatrilat reduce blood pressure and improve resistance artery structure and function in stroke-prone spontaneously hypertensive rats?

Population

10-week-old stroke-prone spontaneously hypertensive rats (SHRSP)

Intervention

Omapatrilat (40 mg/kg per day) administered orally for 10 weeks

Comparator

Untreated stroke-prone spontaneously hypertensive rats (SHRSP)

Outcome

Systolic blood pressure, structure and endothelial function of mesenteric resistance arteries (lumen <300 microm)surrogate

Omapatrilat potently reduces blood pressure and improves the structure and endothelial function of resistance arteries in a severe genetic model of hypertension.

Cite This Study

Intengan et al. (2000) studied this question.

synapsesocial.com/papers/6a729e5335aa2c282ce358a6 https://doi.org/10.1161/01.hyp.35.6.1221

Topics

Hypertension management

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Vasopeptidase Inhibition Has Potent Effects on Blood Pressure and Resistance Arteries in Stroke-Prone Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Vasopeptidase Inhibition Has Potent Effects on Blood Pressure and Resistance Arteries in Stroke-Prone Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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