Emerging treatments for hypertension: potential role for vasopeptidase inhibition
Why the study?
Do vasopeptidase inhibitors like omapatrilat reduce blood pressure in patients with hypertension?
Population
Patients with hypertension
Design
Review
Authors
Discussion
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Member takes
Implication
Supports further development of omapatrilat; leaves open comparative efficacy and safety versus established agents.
Structured PICO
Do vasopeptidase inhibitors like omapatrilat reduce blood pressure in patients with hypertension?
P
Population
Patients with hypertension
I
Intervention
Vasopeptidase inhibitors (specifically omapatrilat administered orally once daily)
O
Outcome
Reduction of systolic and diastolic blood pressuressurrogate
Vasopeptidase inhibitors like omapatrilat represent a promising class of antihypertensive agents that effectively lower blood pressure by simultaneously inhibiting neutral endopeptidase and ACE.
Cite This Study
Michael A. Weber (1999) studied this question.