Why the study?
Acute thrombosis poses a high risk of major cardiovascular events, motivating a synthesis of the roles of cell-derived extracellular vesicles to facilitate future targeted therapies.
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Design
Review
May guide EV-targeted diagnostics and therapies in thrombosis; leaves open prospective trials before clinical adoption.
The risk of cardiovascular events caused by acute thrombosis is high, including acute myocardial infarction, acute stroke, acute pulmonary embolism, and deep vein thrombosis. In this review, we summarize the roles of extracellular vesicles of different cellular origins in various cardiovascular events associated with acute thrombosis, as described in the current literature, to facilitate the future development of a precise therapy for thrombosis caused by such vesicles. We hope that our review will indicate a new horizon in the field of cardiovascular research with regard to the treatment of acute thrombosis, especially targeting thrombosis caused by extracellular vesicles secreted by individual cells. As more emerging technologies are being developed, new diagnostic and therapeutic strategies related to EVs are expected to be identified for related diseases in the future.
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He et al. (2022) studied this question.
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