November 1, 1985BloodOpen Access

beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway

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Population

In vitro plasma models (normal or beta 2-glycoprotein I-deficient plasma)

Design

Preclinical

Authors

Discussion

No immediate clinical implications; leaves open whether beta2-GPI modulation affects human thrombosis risk.

Population

In vitro plasma models (normal or beta 2-glycoprotein I-deficient plasma)

Intervention

Addition of beta 2-glycoprotein I

Outcome

Inhibition of the contact phase system of the intrinsic pathway of blood coagulation (measured by amidolytic activity)surrogate

Beta 2-glycoprotein I functions as an inhibitor of the contact activation of the intrinsic blood coagulation pathway.

Inger Schousboe (1985) studied this question.

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