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November 20, 2014International Journal of EpidemiologyOpen Access

Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1 937 360 people in England: lifetime risks and implications for risk prediction

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Why the study?

Does current smoking increase the risk of various initial presentations of cardiovascular disease in adults aged ≥30 years without prior CVD?

Population

1,937,360 people aged ≥30 years, with no history of cardiovascular disease, drawn from linked electronic…

Comparison

Current smoking vs Never smoking

Design

Cohort

Follow-up

11.6 million person-years

Authors

MPMar Pujades‐RodríguezPreventive CardiologyJGJulie GeorgeBeaumont Hospital, TroyASAnoop D ShahGeneral Cardiology

Discussion

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Implication

Heterogeneous smoking risks by CVD subtype may inform counseling; leaves open causal mechanisms in observational cohorts.

Structured PICO

Does current smoking increase the risk of various initial presentations of cardiovascular disease in adults aged ≥30 years without prior CVD?

P
Population
1,937,360 people aged ≥30 years, with no history of cardiovascular disease, drawn from linked electronic health records in England (1997-2010)
I
Intervention
Current smoking
C
Comparator
Never smoking
O
Outcome
Lifetime cumulative incidence of 12 initial non-fatal or fatal cardiovascular disease presentationshard clinical

Smoking exhibits highly heterogeneous associations with different initial cardiovascular disease presentations, with the strongest risks for peripheral arterial disease and abdominal aortic aneurysm, which remain elevated even 10 years after quitting.

Cite This Study

Pujades‐Rodríguez et al. (2014) studied this question.

synapsesocial.com/papers/6a72a7ca35aa2c282ce35d2chttps://doi.org/10.1093/ije/dyu218

Topics

Women and heart disease
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