March 1, 1980Clinical Pharmacology & Therapeutics
Hemodynamic evaluation of hydralazine dosage in refractory heart failure
Why the study?
Do different doses of hydralazine produce varying hemodynamic improvements in patients with severe refractory heart failure?
Population
18 patients with severe refractory resistant heart failure
Design
Case_series
Authors
Discussion
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Member takes
Implication
May warrant individualized hydralazine dosing in renal impairment; case report leaves open prospective validation in refractory HF.
Structured PICO
Do different doses of hydralazine produce varying hemodynamic improvements in patients with severe refractory heart failure?
P
Population
18 patients with severe refractory resistant heart failure
I
Intervention
Hydralazine at varying single doses (50 mg, 75 mg, 100 mg, and 150 to 200 mg)
O
Outcome
Hemodynamic responses including cardiac index (CI), systemic vascular resistance (SVR), mean arterial pressure (MAP), left ventricular filling pressure (LVFP), stroke work index (SWI), and duration of actionsurrogate
The hemodynamic response to hydralazine in severe heart failure is highly variable and requires individualized dosing, with longer duration of action in patients with renal impairment.
Cite This Study
Packer et al. (1980) studied this question.