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September 1, 1980HeartOpen Access

Haemodynamic effects of hydralazine at rest and during exercise in patients with chronic heart failure.

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Why the study?

Does hydralazine improve haemodynamic parameters at rest and during exercise in severely symptomatic patients with chronic left ventricular failure?

Population

n=10 severely symptomatic patients with chronic left ventricular failure from diffuse coronary disease or…

Comparison

Hydralazine vs Pretreatment measurements (baseline)

Design

Case_series

Authors

WGW. R. GinksDRD R Redwood

Discussion

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Overview

May improve exercise hemodynamics in severe chronic LV failure; extends rest data but hypothesis-generating.

Key Points

  • This study aims to evaluate the effects of hydralazine on haemodynamics at rest and during exercise in patients with chronic heart failure.
  • Administered hydralazine to 10 patients with chronic left ventricular failure at rest and during exercise on a bicycle ergometer.
  • Patients were already on optimal treatment with digitalis and diuretics.
  • At rest, hydralazine reduced mean arterial and pulmonary wedge pressure and systemic vascular resistance by 50%.
  • During exercise, there was a 20% decrease in arterial resistance and a 20% increase in stroke volume index compared to control.

Structured PICO

Does hydralazine improve haemodynamic parameters at rest and during exercise in severely symptomatic patients with chronic left ventricular failure?

P
Population
n=10 severely symptomatic patients with chronic left ventricular failure from diffuse coronary disease or cardiomyopathy, already receiving optimal treatment with digitalis and diuretics.
I
Intervention
Hydralazine
C
Comparator
Pretreatment measurements (baseline)
O
Outcome
Haemodynamic parameters (mean arterial pressure, pulmonary wedge pressure, systemic vascular resistance, stroke volume index) at rest and during upright exercise on a bicycle ergometersurrogate

Hydralazine improves cardiac haemodynamics both at rest and during upright exercise in patients with severe chronic left ventricular failure.

Cite This Study

Ginks et al. (1980) studied this question.

synapsesocial.com/papers/6a1d9667cc9f7df1b705aaechttps://doi.org/10.1136/hrt.44.3.259
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