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August 1, 1983CirculationOpen Access

Effect of hydralazine on perfusion and metabolism in the leg during upright bicycle exercise in patients with heart failure.

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Why the study?

Does intravenous hydralazine improve O2 transport to working muscle during maximal upright bicycle exercise in patients with chronic heart failure?

Population

10 patients with chronic heart failure

Comparison

Intravenous hydralazine vs Baseline (pre-hydralazine)

Design

Other

Authors

JWJohn R. WilsonJMJack L. MartinNFNancy Ferraro

Discussion

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Overview

Does not enhance muscle O2 uptake in HF despite higher flow; leaves open vasodilator effects on exercise capacity and functional shunting.

Key Points

  • The study aims to evaluate whether hydralazine improves oxygen transport to working muscle during exercise in heart failure patients.
  • Intravenous hydralazine was administered to 10 patients with chronic heart failure during maximal upright bicycle exercise.
  • Blood flow and metabolic parameters were measured using thermodilution and lactate levels.
  • Maximal exercise cardiac output, systemic oxygen extraction, and leg blood flow were assessed before and after hydralazine administration.
  • Cardiac output increased from 5.6 to 6.7 l/min (p < 0.01).
  • Systemic oxygen extraction decreased from 79% to 65% (p < 0.01).
  • Leg blood flow increased from 1.6 to 2.1 l/min (p < 0.03) with unchanged peak femoral venous lactate levels.

Structured PICO

Does intravenous hydralazine improve O2 transport to working muscle during maximal upright bicycle exercise in patients with chronic heart failure?

P
Population
10 patients with chronic heart failure
I
Intervention
Intravenous hydralazine
C
Comparator
Baseline (pre-hydralazine)
O
Outcome
Blood flow (measured by thermodilution) and metabolism in the leg during maximal upright bicycle exercisesurrogate

Intravenous hydralazine increases leg blood flow during exercise in heart failure patients but does not improve oxygen availability to working muscle, suggesting functional shunting.

Cite This Study

Wilson et al. (1983) studied this question.

synapsesocial.com/papers/6a16c06b0f965e9c137b9155https://doi.org/10.1161/01.cir.68.2.425
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Haemodynamic effects of hydralazine at rest and during exercise in patients with chronic heart failure.1980 · 19 citations
  2. 2Rest and exercise hemodynamic effects of oral hydralazine in patients with coronary artery disease and left ventricular dysfunction.1980 · 33 citations
  3. 3Effects of hydralazine on coronary blood flow and myocardial energetics in congestive heart failure.1982 · 36 citations
  4. 4Beneficial effects of hydralazine on rest and exercise hemodynamics in patients with chronic severe aortic insufficiency.1980 · 99 citations
  5. 5Effects of oral hydralazine on rest and exercise hemodynamics in patients with aortic or mitral regurgitation and left ventricular dysfunction1981 · 4 citations