Why the study?
Does acute administration of oral hydralazine and isosorbide dinitrate improve exercise capacity and hemodynamics in patients with class II or III congestive heart failure?
Population
22 patients with class II or III congestive heart failure (CHF)
Comparison
Oral hydralazine and isosorbide dinitrate… vs Placebo administered 90 minutes before exercise
Design
RCT, random, double-blind
Follow-up
90 minutes after administration
Authors
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Does not improve maximal exercise capacity in HF; extends submaximal hemodynamic benefits of hydralazine-isosorbide dinitrate without peak gains.
Does acute administration of oral hydralazine and isosorbide dinitrate improve exercise capacity and hemodynamics in patients with class II or III congestive heart failure?
Acute administration of hydralazine and isosorbide dinitrate does not improve maximal exercise capacity but improves hemodynamics at submaximal workloads in patients with heart failure.
Franciosa et al. (1979) studied this question.
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