Why the study?
Does oral hydralazine and sublingual isosorbide dinitrate improve hemodynamics and exercise tolerance in patients with chronic heart failure?
Does oral hydralazine and sublingual isosorbide dinitrate improve hemodynamics and exercise tolerance in patients with chronic heart failure?
Combination therapy with oral hydralazine and sublingual isosorbide dinitrate provides sustained improvements in resting and exercise hemodynamics, as well as exercise tolerance, in patients with chronic heart failure.
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May improve exercise tolerance in chronic HF; hypothesis-generating, requiring randomized confirmation before practice change.
Massie et al. (1981) studied this question.