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July 1, 1981Clinical Cardiology

Effects of oral hydralazine on rest and exercise hemodynamics in patients with aortic or mitral regurgitation and left ventricular dysfunction

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Why the study?

Does oral hydralazine improve rest and exercise hemodynamics in patients with aortic or mitral regurgitation and left ventricular dysfunction?

Population

11 patients with aortic or mitral regurgitation and left ventricular dysfunction who are not candidates for…

Comparison

Oral hydralazine 50-70 mg every 6 hours for 48… vs Baseline (before hydralazine administration).

Design

Case_series

Follow-up

48 hours

Authors

DSDavid SloskyMHMichael C. HindmanRPRobert H. Peter

Discussion

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Overview

Oral hydralazine provides favorable hemodynamic effects at rest and during exercise in patients with aortic or mitral regurgitation and LV dysfunction who are not surgical candidates.

Structured PICO

Does oral hydralazine improve rest and exercise hemodynamics in patients with aortic or mitral regurgitation and left ventricular dysfunction?

P
Population
11 patients with aortic or mitral regurgitation and left ventricular dysfunction who are not candidates for surgical valve replacement.
I
Intervention
Oral hydralazine 50-70 mg every 6 hours for 48 hours.
C
Comparator
Baseline (before hydralazine administration).
O
Outcome
Hemodynamic parameters (heart rate, mean arterial pressure, systemic vascular resistance, oxygen consumption, arteriovenous oxygen difference, pulmonary capillary wedge pressure) at rest and during two levels of upright exercise.surrogate

Oral hydralazine provides favorable hemodynamic effects at rest and during exercise in patients with aortic or mitral regurgitation and LV dysfunction who are not surgical candidates.

Cite This Study

Slosky et al. (1981) studied this question.

synapsesocial.com/papers/6a703937e5469ee92be0fa54https://doi.org/10.1002/clc.4960040403
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