Beneficial effects of hydralazine in severe mitral regurgitation.
Why the study?
Does hydralazine improve hemodynamics in patients with severe mitral regurgitation?
Population
10 patients with severe mitral regurgitation
Design
Case_series
Follow-up
at least 48 hours
Authors
Discussion
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Member takes
Implication
May support acute use in severe MR; leaves open efficacy and outcomes in randomized trials.
Key Points
- The aim is to evaluate the effects of hydralazine on hemodynamics in patients with severe mitral regurgitation.
- Intravenous hydralazine administered to 10 patients with severe mitral regurgitation.
- Measurement of forward stroke volume and regurgitant stroke volume before and after treatment.
- Assessment of hemodynamic parameters, including pulmonary capillary wedge pressure.
- Forward stroke volume increased significantly from 22 +/- 2 to 33 +/- 3 ml/m2 (P < 0.001).
- Regurgitant stroke volume decreased significantly from 40 +/- 6 to 27 +/- 6 ml/m2 (P < 0.001).
- Hydralazine maintained hemodynamic improvements for at least 48 hours.
Structured PICO
Does hydralazine improve hemodynamics in patients with severe mitral regurgitation?
P
Population
10 patients with severe mitral regurgitation
I
Intervention
Intravenous hydralazine followed by oral hydralazine
O
Outcome
Hemodynamic response (forward stroke volume and regurgitant stroke volume)surrogate
Hydralazine acutely improves hemodynamics in severe mitral regurgitation by reducing aortic impedance, leading to increased forward stroke volume and decreased regurgitant volume.
Cite This Study
Greenberg et al. (1978) studied this question.