Why the study?
Does pregnancy alter the pharmacokinetics and pharmacodynamics of atenolol in women with preexisting hypertension compared to postpartum?
Population
17 pregnant women with preexisting hypertension
Comparison
Steady-state oral atenolol vs 3 months postpartum (nonpregnant control)
Design
Cohort
Follow-up
3 months postpartum
Authors
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May support closer atenolol monitoring in pregnancy; hypothesis-generating for bioavailability-adjusted dosing trials.
Does pregnancy alter the pharmacokinetics and pharmacodynamics of atenolol in women with preexisting hypertension compared to postpartum?
Pregnancy increases the renal clearance of atenolol, but this does not translate into an increase in apparent oral clearance, likely due to high variability in bioavailability.
Hébert et al. (2004) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: