Why the study?
Does propofol improve left ventricular diastolic function in dogs with dilated cardiomyopathy?
Population
7 dogs with pacing-induced dilated cardiomyopathy (paced at 240 beats/min for 18 +/- 3 days)
Comparison
Propofol vs Baseline hemodynamics in sinus rhythm in the…
Design
Preclinical
Follow-up
15 min of equilibration at each dose
Authors
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Propofol impairs early-diastolic filling in canine dilated cardiomyopathy despite unloading; leaves open translation to human heart failure.
Does propofol improve left ventricular diastolic function in dogs with dilated cardiomyopathy?
In a canine model of dilated cardiomyopathy, propofol reduces preload and afterload but exerts direct negative inotropic effects and impairs early-diastolic filling.
Pagel et al. (1998) studied this question.
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