Why the study?
Does propofol affect the function of normal, collateral-dependent, and ischemic myocardium differently in a canine model?
Population
9 mongrel dogs chronically instrumented with hydraulic occluders and ameroid constrictors around the left…
Comparison
Propofol (5 mg/kg intravenous bolus) vs Normal and collateral-dependent myocardium
Design
Preclinical
Follow-up
3 minutes
Authors
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May caution propofol dosing in acute ischemia; hypothesis-generating for differential effects in human myocardium.
Does propofol affect the function of normal, collateral-dependent, and ischemic myocardium differently in a canine model?
In a canine model, an intravenous bolus of propofol impairs the function of acutely ischemic myocardium significantly more than normal or collateral-dependent myocardium.
Mayer et al. (1993) studied this question.
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